Spatial Moran Models I. Stochastic Tunneling in the Neutral CaseE

Rick Durrett and Stephen Moseley

Abstract. We consider a multistage cancer model in which cells are arranged in a d-dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensions d = 2, and 3, extending work done by inspired by Komarova (2007) for d = 1.

Ann. Appl. Prob. 25, 104-115

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